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In some patientsthe administration of a non-steroidal anti-inflammatory agent can reduce the diureticnatriureticand antihypertensive effects of looppotassium-sparing and thiazide diureticsThereforewhen MIDAMORamilorideand non-steroidal anti-inflammatory agents are used concomitantlythe patient should be observed closely to determine if the desired effect of the diuretic is obtainedSince indomethacin and potassium-sparing diureticsincluding MIDAMORamiloridemay each be associated with increased serum potassium levelsthe potential effects on potassium kinetics and renal function should be considered when these agents are administered concurrently.

This list is not completeOther drugs may interact with amilorideincluding prescription and over-the-counter medicinesvitaminsand herbal productsNot all possible interactions are listed in this medication guide.

This medication can cause high potassium levelshyperkalemiaThis effect is more likely to occur in older adults and in patients with kidney diseasediabetesor a serious illnessPotassium levels must be closely monitored on a regular basis while taking this medicationIf not treatedvery high potassium levels can sometimes be fatalTell your doctor right away if you develop any symptoms of high potassium levelsincluding muscle weaknessslow/irregular heartbeatnumb/tingling skin.

Do not use salt substitutes or low-sodium milk products that contain potassiumThese products could cause your potassium levels to get too high while you are taking amiloride.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

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